If you'd included that quote in its proper context Bossman, it only applies to the anticheat.
Right now, using R1Q2 on Vista, especially on x86-64 is unsupported since I haven't tested it in this configuration, and you'll also be dealing with the WoW system when trying to run 32 bit apps. I recommend you use WinXP x86 when trying to play games.
from what I can tell the R1Q2 client with the software render does run.
and open gl as shipped with the Q2 CD works.
so I think that if the issue with the renderer was found then it would be ok.
I Know Vista is Beta.... I am trying out a bunch of games this weekend and some business stuff also...
just figured I'd let you know what I saw.